Anti-Tr antibodies

Synonyms: PCA-Tr

Clinical associations: Paraneoplastic cerebellar degeneration (PCD).

Tumor associations: Hodgkin disease, rarely, non-Hodgkin lymphoma.

Frequency of anti-Tr antibodies in patients with suspected PCD without evidence of cancer: 11% (3/28)

Frequency of anti-Tr antibodies in patients with Hodgkin disease alone:
0% (30 cases studies)

Screening test:
Immunohistochemistry on frozen rat or mouse cerebellar sections. (figure).

Figure: Rat cerebellum incubated with anti-Tr antibodies. There is staining of the cytoplasm of Purkinje cells and the molecular cell layer with a fine punctate reactivity.

Confirmatory test:
Not available. Antibody not detected by immunoblot

Immunologic associations:
Patients with anti-Tr antibodies frequently have anti-MAZ (myc-associated zinc-finger protein) antibodies. In one study 16 of 19 patients presented both antibodies. However, anti-MAZ antibodies were also present in 16 of 131 controls.

Tr antigen

Unknown

References

1. Bernal F, Shams'ili S, Rojas I, et al. Anti-Tr antibodies as markers of paraneoplastic cerebellar degeneration and Hodgkin's disease. Neurology. 2003;60:230-4.
2. Graus F, Dalmau J, Valldeoriola F et al. Immunological characterization of a neuronal antibody (anti-Tr) associated with paraneoplastic cerebellar degeneration and Hodgkin's disease. J Neuroimmunol 1997;74:55-61.
3. Graus F, Gultekin SH, Ferrer I, et al. Localization of the neuronal antigen recognized by anti-Tr antibodies from patients with paraneoplastic cerebellar degeneration and Hodgkin’s disease in the rat nervous system. Acta Neuropathol 1998;96:1-7.
4. Bataller L, Wade DF, Graus F, et al. The MAZ protein in an auroantigen of Hodgkin’s disease and paraneoplastic cerebellar dysfunction. Ann Neurol 2003 ;53 :123-7.

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