Neurology Service
Secretaría de Neurología
Escalera 8 piso 4
Villarroel, 170
08036 Barcelona
Spain
Tel : ++34-93-227-5414
Fax: ++34-93-227-5783

Dr. Francesc Graus was born in 1953 in Barcelona. Trained in Neurology at CSU Bellvitge, Barcelona from 1977 to 1981 and in Neuro-Oncology at MSKCC, New York from 1982 to 1985. He works since 1986 at the service of Neurology of the Hospital Clinic. Barcelona. He described for the first time the anti-Hu antibodies in 1985. Since then, he has been active in the field of paraneoplastic neurological disorders. His laboratory is a referral center for the determination on onconeural antibodies.

Scientific Team
Francesc Graus MD, Albert Saiz MD, Carles Serra MD, Yolanda Blanco MD, Lidia Sabater BSc, Mercé Bonastre and Eva Caballero lab technicians.

Research facilities
Immunohistochemistry and immunoblot techniques to detect onconeural antibodies. RIA for VGCC antibodies. PCR, RT-PCR, and gene cloning.

Areas of interest:
Correlation of clinical syndromes with immunological profiles and characterization of new antibodies that may help in the diagnosis of these disorders or in the identification of antigens that may be relevant in neuroscience or tumor immunology.

Selected Publications:
1. Molinuevo, J.L.; Graus, F.; Serrano, C.; et al. Utility of anti-Hu antibodies in the diagnosis of paraneoplastic sensory neuropathy. Annals of Neurology 1998; 44: 976-80
2. Bataller, L.; Graus, F.; Saiz, F. et al. Clinical outcome in adult onset idiopathic or paraneoplastic opsoclonus- myoclonus. Brain 2001;124: 437-43.
3. Graus, F.; Keime-Guibert, F.; Reñé, R.; et al. Anti-Hu-associated paraneoplasic encephalomyelitis: analysis of 200 patients. Brain 2001; 124: 1138-48.
4. Graus F.; Lang B.; Pozo-Rosich P.; et al. P/Q type calcium-channel antibodies in paraneoplastic cerebellar degeneration with lung cancer. Neurology 2002; 59: 764-6.
5. Bernal, F.; Shams’ili, S.; Rojas, I.; Sánchez-Valle, R.; Saiz, A.; Dalmau, J.; Honnorat, J.; Sillevis Smitt, P.;Graus, F. Anti-Tr antibodies as markers of paraneoplastic cerebellar degeneration and Hodgkin’s disease. Neurology 2003; 60: 230- 4.