Jean-Yves Delattre

Biologie des Interactions Neurone-Glie
Inserm U 495 Hopital de La Salpetrière
47, Boulevard De La Salpetrière
75651 Paris
France
Tel : +33 1 42 16 03 85
Fax : +33 1 42 16 04 18

Dr. Jean Yves Delattre is Professor of Neurology, Attending Neurologist, and chairman of the Fédération of Neurology « Mazarin », Salpetriere Hospital, Paris. In the Laboratory of Experimental Neuro-Oncology (INSERM U 495), approximatively 2000 sera or CSF are screened each year for the presence of anti-Hu, anti-Yo, anti-Ri, anti-CV2, anti-Tr, anti-Gad and anti-Ta autoantibodies.

Scientific team:
The "Paraneoplatic Neurologic Syndromes" group of the Salpetrière Hospital (Department of Neurology and INSERM U 495) is constitued by 3 phycians (Jean-Yves DELATTRE, Baya BENYAHIA, Antoine CARPENTIER) and 2 technicians (one on a part time basis).

Research facilities
Immunohistochemistry and immunoblot techniques to detect onconeural antibodies. Cell cultures (tumors and lymphocytes). Cytotoxicity assays.

Areas of interest
Clinical immunological correlations and therapeutic trials in PNS (in close collaboration with Dr F.Graus from Barcelona).
Investigations of the role of cell mediated immunity in the anti-Hu syndrome.
Experimental models of paraneoplastic neurologic syndromes (e.g. HuD-cDNA vaccination).

Selected Publications

1. S. Alamowitch, F.Graus, M.Uchuya, et al. Limbic encephalitis and small cell lung cancer: clinical and immunological features. Brain 1997, 120: 923-28.
2. Uchuya M, Fleury A, Graus F, et al. Lack of association between human leukocyte antigens and the anti-Hu syndrome in patients with small-cell lung cancer. Neurology 1998;50:565-6
3. Carpentier AF, Rosenfeld MR, Delattre JY, et al. DNA vaccination with HuD inhibits growth of a neuroblastoma in mice. Clin Cancer Res 1998 Nov;4(11):2819-24
4. Benyahia B, Liblau R, Merle-Beral H, et al. Cell-mediated autoimmunity in paraneoplastic neurological syndromes with anti-Hu antibodies. Ann Neurol 1999;45:162-7
5. F.Keime-Guibert, F.Graus, P.Broet, et al. Clinical outcome of patients with anti-Hu-associated encephalomyelitis after treatment of the underlying tumor. Neurology 1999; 53: 1719-23.