Josep Dalmau

Department of Neurology, 3 W. Gates (Section Neuro-oncology)
University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Phone: 215-746-4707; Fax: 215-746-4717
Website: http://pennhealth.com/neuro/services/neuro_onc/

Dr. Josep Dalmau received his M.D. and Ph.D. from the Autonoma University of Barcelona in Spain where he also completed an internship in Internal Medicine and a residency in Neurology. He completed fellowship training in Neuro-oncology at the Memorial Sloan-Kettering Cancer Center in New York where he was appointed to the faculty at the completion of his fellowship. Dr. Dalmau is currently an Associate Professor of Neurology at the University of Pennsylvania, School of Medicine, and the Director of the Neuro-oncology Laboratory.

Scientific Team
Josep Dalmau, MD, PhD, Myrna R. Rosenfeld, MD, PhD, Patricio Meneses, PhD, Marc A. Dichter, MD, PhD, Adriana Zupa-Fernandez, BA, Amy Felder, RN, Shannon Leon, BA.

Research Facilities
General molecular biology including PCR, RT-PCR, Southern and Northern blotting, serologic screening phage expression libraries, immunohistochemistry, immunoblot, immunoprecipitation.

Areas of Interest
His research focuses on cancer induced neuroimmunological disorders, called paraneoplastic neurologic syndromes. These studies comprise cloning and characterization of onconeuronal genes that can be used as markers of neurological diseases and cancers, and the study of the mechanisms of neuronal injury caused by cancer-induced immune responses.

Selected Publications
1. Bataller L, Wade DF, Graus F, Stacey HD, Rosenfeld MR, Dalmau J. Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. Neurology 2004;62:778-782.
2. Bataller L, Rosenfeld MR, Graus F, Vilchez JJ, Cheung NK, Dalmau J. Autoantigen diversity in the opsoclonus-myoclonus syndrome. Ann Neurol 2003;53:347-353.
3. Rosenfeld MR, Eichen J, Wade D, Posner JB, Dalmau J. Molecular and clinical diversity in paraneoplastic immunity to Ma proteins. Ann Neurol 2001;50:339-348.
4. Gultekin SH, Rosenfeld MR, Voltz R, Eichen J, Posner JB, Dalmau J. Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings, and tumor association in 50 patients. Brain 2000;123:1481-1494.
5. Voltz R, Gultekin SH, Rosenfeld MR, Gerstner E, Eichen J, Posner JB, Dalmau J. A serological marker of paraneoplastic limbic and brainstem encephalitis in patients with testicular cancer. N Engl J Med 1999;340:1788-1795.