Jean-Christophe Antoine
Department of Neurology
Boulevard Pasteur
42055 Saint-Etienne
France
Tel : +33 04 77127805
Fax: +33 04 77 120543
Dr. Jean-Christophe Antoine is a neurologist working
in the Neuromuscular System Degeneration Laboratory, Faculté
de Médecine Jacques Lisfranc, Saint-Etienne, France. His laboratory
is involved in diagnostic and research fields for paraneoplastic neurological
syndromes since 1990.
Scientific Team
Jean-Christophe Antoine, MD.; Jean-Philippe Camdessanché, MD.;
Léna Absi, MD.; François Lassablière, technician;
Karine Ferraud, clinical research assistant.
Research facilities
Immunohistochemistry and immunoblot techniques to detect onconeural
antibodies. Molecular biology (RT-PCR, in situ hybridisation), cell
culture, animal model of neuropathy.
Areas of interest:
The study of the expression of the antigen recognized by anti-CV2
antibodies (CRMP proteins) in the tumour of patients and in the
peripheral nervous system and paraneoplastic disorders of the peripheral
nervous system.
Selected Publications:
1. Antoine JC, Mosnier JF, Absi L, et al. Carcinoma associated paraneoplastic
peripheral neuropathies in patients with and without anti-onconeural
antibodies. J
Neurol Neurosurg Psychiatry 1999 ; 67 : 7-14 .
2. J Honnorat, T Byk, I Kusters, et al. ULIP/CRMP proteins are recognized
by autoantibodies in paraneoplastic neurological syndromes. European
Journal of Neurosciences. 1999 ; 11: 4226-32
3. JC Antoine, L Cinotti, C Tiliket, et al. Interest of FDG PET Scanner
in the Diagnosis of Cancer in Patients with Paraneoplastic Neurological
Syndrome and Anti-Hu Antibodies. Annals
of Neurology. 2000 ; 48 : 105-8.
4. JC Antoine, J Honnorat, JP Camdessanché, et al. Paraneoplastic
anti-CV2 antibodies react with peripheral nerve and are associated with
a mixed axonal and demyelinating peripheral neuropathy. Annals
of Neurology. 2001.49 : 214-21.
5. JP Camdessanché, JC Antoine, J Honnorat, et al. Paraneoplastic
peripheral neuropathy associated with anti-Hu antibodies. A clinical
and electrophysiological study of 20 patients. Brain.
2002 ; 125 :166-175
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